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Response to reviewer 2:
Response to comment:The relevance of this work in the clinical practice is very poor. The knowledge of precise concentrations of tumor markers in normal healthy adult for cancer screening and diagnosis is useless.
Response: Tumor marker tests are not used alone to detect and diagnose cancer because most tumor markers can be elevated in patients who don't have a tumor. Although tumor markers are typically imperfect as screening tests to detect hidden cancers, once a particular tumor has been found with a marker, the marker may be a marvel as a means of monitoring the success (or failure) of treatment. The tumor marker level may also reflect the extent (the stage) of the disease, indicate how quickly the cancer is likely to progress and so help determine the prognosis. The acquaintance of whether the level of serum tumor maker is abnormal is based on cut-off level. Moreover, the current research about reference intervals for serum AFP and CEA is the first published report regarding Chinese populations. Therefore, this study is of great significance.
I have rewrite “Assessment of the clinical value of serum tumor markersrequires knowledge about their precise concentrations in normal healthy adults” to “The knowledge about the cut-off level of tumor markers may help distinguish between benign and malignant disease” (line 6, page 3).
4. 后面我又经历了一次小修，就不再赘述。接下来是负责排版的editor来信要确实最终的proof，及填写单印本订购单（OFFPRINT ORDER FORM)和版权转让表（COPYRIGHT TRANSFER FORM)，问了师兄师姐及园子里德战友的意见，大家都够单印本可以不要（如果要是要几百欧元的，贵啊)，我就直接在回信里拒绝了，COPYRIGHT TRANSFER FORM我填好以后给老板签字，然后又扫描成pdf转发给编辑，下面是我的回信
Dear Sir/Madame Campori,
Thank you for sending the galley proofs of the article to us and your kindly reminding. We have checked the galley proofs carefully including typographical errors, proper placement of pictures and tables, omissions and specific editor’s queries. We reply as follow:
1. In the text we found in red the questions
Response: Thank you for your reminding and we approved of all the changes after discussion. In the text, “Male Healthy and Examination Survey” should be replaced with “Male Health and Examination Survey” and the change of “The 1-sided nonparametric RIs” is OK.
2. Fig. 1 - whether we want to have color picture?
Response: We really apologize for having submitted the color picture. We want all the pictures to be published in black and white.
3. The “OFFPRINT ORDER FORM”
Response: we feel very sorry to tell you that we do not need the offprints of our paper and the offprint order form is not filled in.
We are looking forward to publishing our article and send our best regards
5.最后还出现了个小插曲，编辑回信叫我最后确认下proof有没有错误，因为是用老板的邮箱通讯作者，结果竟然等到过了二十几天才看到邮件（心里暗暗骂了他几句)，赶紧回信确认并解释，还好只是虚惊一场。医.学全.在.线网站www.lindalemus.com搜集整理。
Dear Sir/Madame Campori,
We feel terribly sorry for our deferred letter.We were all immersed in the joy of the Spring Festivalin which is Chinese traditional New Year.We had a long holiday and got to a trip so as to did not see your letter in time. We have checked the final PDF and everything is ok.We deeply hope our fault does not cause you too much trouble and looking forward to publishing our article.
Thank you
Best regards
署名
最最后就是在昨天我发现我的文章在网上可以查到了（兴奋啦，激动啊)，在这里要感谢曾经帮助过我的战友们，前面写的内容如有不当之处请指正，谢谢大家。
